The NLRP3 inflammasome, a key mediator of neuroinflammation, has emerged as a critical player in AD pathogenesis, contributing to the accumulation of β-amyloid (Aβ) plaques, tau hyperphosphorylation, ...

The initiation and activation of the inflammasome are intricately involved in the onset of MS. Notably, the NLRP3 inflammasome, the most extensively studied member of the inflammasome complex, is ...

NLRP3 inflammasome inhibitors are described in a Zomagen Biosciences Ltd. patent and are reported to be useful for the treatment of autoimmune, cardiovascular, inflammatory, liver, lung, metabolic and ...

接着，研究人员探究了棕榈酰化是如何促进炎症小体形成的。通过活细胞显微镜观察，他们发现，受到 NLRP3 激活剂刺激后，NLRP3 会迅速在细胞质中形成具有动态、液体样行为的斑点，这和液 - 液相分离（LLPS）的特征相符。而且这个过程完全依赖于棕榈酰化，没有棕榈酰化的 NLRP3 无法形成斑点，也不能支持炎症小体激活。

NLRP3 is a member of a family of proteins known as inflammasome receptors and is a key component of the NLRP3 inflammasome, which is implicated in a host of diseases characterised by runaway ...

SAN DIEGO, April 01, 2025 (GLOBE NEWSWIRE) -- Ventyx Biosciences, Inc. (Nasdaq: VTYX) (“Ventyx”, “Company”), a clinical-stage biopharmaceutical company ...

The new SAB members have made vital discoveries in understanding the role of the NLRP3 inflammasome in neuro- and systemic inflammation, and are at the forefront of clinical development in ...