The activation of the NLRP3 inflammasome is a key factor driving kidney inflammation, but it remains unclear whether CRP enhances inflammation in DKD through the NLRP3 inflammasome pathway.

Scientists from F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have patented NLRP3 inflammasome and interleukin-1β (IL1B; IL-1β) release inhibitors reported to be useful for the treatment of ...

Then, in 2001, researchers in California discovered the genetic explanation for his disease: a mutation in a gene called CIAS1 (since renamed NALP3 and then NLRP3), which was later found to cause the ...

Appointment of seven recognized experts is validating for Ventyx’s NLRP3 Program--AD/PD™ 2025 provides helpful insights on potential next steps ...

Get Instant Summarized Text (Gist) Isocyanic acid (ICA), a metabolite produced by the enzyme LACC1, has been identified as an anti-inflammatory agent. ICA disrupts NLRP3 inflammasome activation in ...

The NLRP3 inflammasome is implicated in a host of diseases characterised by runaway inflammation, and Inflazome has completed phase 1 testing of two drugs – inzomelid and somalix – that are ...

SAN DIEGO, April 01, 2025 (GLOBE NEWSWIRE) -- Ventyx Biosciences, Inc. (Nasdaq: VTYX) (“Ventyx”, “Company”), a clinical-stage biopharmaceutical company ...