In summary, augmenting early insulin secretion is a remarkably effective mechanism to control postprandial hyperglycemia. Low-dose nateglinide could be used to determine the potential of this ...

This multicenter, double-blind, randomized, parallel-group fixed-dose study of 8 weeks' duration was performed to define the maximum tolerated dose of nateglinide in a prediabetic population.

The Clean Development Mechanism (CDM), defined in Article 12 of the Protocol, allows a country with an emission-reduction or emission-limitation commitment under the Kyoto Protocol (Annex B Party) to ...

Enzyme mechanisms are the chemical transformations, and the steps within them, generated by enzymatic action on substrates. The mechanism of enzyme catalysis is similar in principle to other types ...

Lissencephaly is a severe neurodevelopmental disease often caused by mutations in the Dcx gene. Using a human cellular model of lissencephaly, the authors report that DCX restricts neuronal ...

The most commonly mutated ALS-linked genes are reviewed with an emphasis on disease-causing mechanisms. The cellular processes involved in ALS pathogenesis are discussed, with evidence implicating ...

Type 2 diabetes is a form of diabetes characterized by high blood sugar (glucose), insulin resistance, and a decrease in insulin production. For some people, type 2 diabetes can be managed with ...

Many genetic variants in drug metabolizing enzymes and transporters have been shown to be relevant for treating psychiatric disorders. Associations are strong enough to feature on drug labels and for ...

Competitive kinetic isotope effects can also be determined. The resultant data are expected to be useful in the construction of predictive models across several dimensions including reaction ...