It is interesting to note that mitochondria are crucial for controlling ROS homeostasis. Moreover, system Xc −, Nrf2, and GPX4 are the primary regulators of ferroptosis. (Abbreviations: VDAC, ...

Ferroptosis is iron-dependent regulatory cell death (RCD). Morphologically, ferroptosis is manifested as mitochondrial atrophy and increased mitochondrial membrane density. Biochemically, ferroptosis ...

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...