Ferroptosis was determined by MDA levels, SOD levels, mitochondrial iron accumulation and ROS production. Ferroptosis-related proteins Slc7a11, Nrf2 and Gpx4 levels were measured by western blot, ...

It is interesting to note that mitochondria are crucial for controlling ROS homeostasis. Moreover, system Xc −, Nrf2, and GPX4 are the primary regulators of ferroptosis. (Abbreviations: VDAC, ...

Sulforaphane is a sulfur-rich compound found in certain species of the Brassica vegetable family. It's found in broccoli and other cruciferous vegetables, like bok choy, kale, and cabbage.

We further treated the cells with CHIR99021, an activator of the Wnt signaling pathway. The results showed that CHIR99021 activated the GSK3β/β-catenin signaling pathway and reversed the PFOA-induced ...

In this manuscript, the authors consider the effects of eugenol (EUG), a plant-produced substance known to reduce oxidative stress in various cellular contexts via Nrf2, in alleviating the effects of ...

Objective Investigating the effect of ferroptosis in the tumour microenvironment to identify combinatory therapy for liver cancer treatment. Design Glutathione peroxidase 4 (GPx4), which is considered ...

This is the machine learning pipeline and web service of the research: Single-cell Reactive Oxygen Species Regulome Profiling Reveals Dynamic Redox Regulation in Immune Cells Yi-Chuan Wang; Ping-Hsun ...

Department of Radiology, Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210008, China ...

随着生活环境以及饮食结构的改变，结直肠癌（colorectal cancer ，CRC ）发病率逐年上升[1] 。根据最新数据，从1990 ～2019 年，结直肠癌患病人数增加了1 倍多，成为继肺癌、乳腺癌后发病率第3 的恶性肿瘤，并以9.4% 的高死亡率稳居癌症疾病第2 位，严重危害全球 ...

They were closed with 5% skim milk for 2 h and mixed overnight at 4 °C with primary antibodies EZH1 (ab263961, Abcam), GAPDH (Abcam; ab37168), Bax (Abcam; ab32503), Bcl-2 (Abcam; ab182858), Nuclear ...