编辑推荐：针对黑色素瘤高转移性、化疗耐药等临床难题，昆明医科大学团队揭示了MTCH2通过促进NRF2核转位上调RRM1表达的新机制，证实靶向RRM1可显著增强达卡巴嗪疗效，为克服化疗耐药提供了新靶点。该研究发表于《Cell Death and Disease》，具有重要转化价值。

糖尿病足溃疡（DFU）治疗棘手，尚无特效药物。研究人员开展了 SIRT6 对 DFU 伤口愈合作用的研究。结果发现 SIRT6 过表达可加速 DFU 伤口愈合，其机制与激活 Nrf2 通路有关。该研究为 DFU 治疗提供了新靶点，具有重要临床意义。 糖尿病，这个现代社会的 “健康杀手 ...

When you chop, chew, or blend these vegetables, they release sulforaphane, a compound that triggers the Nrf2 pathway—essentially your cells’ master regulator of antioxidant defense.

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