在生命的长河中，衰老就像一个神秘的 “敌人”，不仅让我们的身体机能逐渐衰退，还悄无声息地增加了众多慢性疾病的患病风险。随着全球老龄化的加剧，如何延缓衰老、促进健康老龄化，成为了现代医学和生命科学领域亟待攻克的难题。

巨噬细胞在人体中发挥着至关重要的作用，它不仅参与到身体的发育和组织修复过程中，还肩负着抵御微生物侵袭的重任。当身体遭遇感染或损伤时，单核细胞就像接到紧急指令的士兵，迅速增殖并奔赴 “战场”，在到达指定位置后，单核细胞会逐渐成熟，变身为具有强大战斗力的巨噬细胞，它们能够有效地对抗入侵的病原体，守护身体的健康。然而，科学家们对于单核细胞向巨噬细胞转变过程中的一些关键机制，尤其是在 mRNA ...

癌细胞之所以可怕，是因为它们“劫持”了细胞周期的调控系统，像一辆失控的列车，疯狂分裂、扩散。正常情况下，细胞周期分为G1（生长期）、S（DNA复制期）、G2（准备期）和M（分裂期）四个阶段，每个阶段都有严格的“检查点”控制。然而，癌细胞通过“篡改”这些检查点，逃避了程序性死亡，最终形成肿瘤。

Dr. Vinod Balachandran says mRNA vaccines could stimulate the immune system to recognize and attack pancreatic cancer cells. An experimental approach to treating pancreatic cancer with the messenger ...

A lipid nanoparticle system has been developed to deliver mRNA across the blood-brain barrier via intravenous injection, overcoming a significant challenge in treating brain diseases.

Blood–brain-barrier-crossing lipid nanoparticles for mRNA delivery to the central nervous system. Nature Materials , 2025; DOI: 10.1038/s41563-024-02114-5 Cite This Page : ...

Protein changes in p21, p53, cyclin A1, cyclin A2, and cyclin E1 were consistent with the mRNA changes (P < 0.01). Additionally, the HIF-1α level of the HG + Rot group was significantly higher than ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The adipokine apelin has been directly ...