胶质母细胞瘤（GBM）临床治疗效果差，免疫治疗对多数患者疗效不佳。研究人员开展联合抗 PD-L1 和抗 VEGFR2 疗法治疗 GBM 的研究。结果显示该联合疗法可调节肿瘤微环境（TME），抑制 GBM 细胞免疫逃逸，延长小鼠生存期，为 GBM 治疗提供新思路。

This manuscript demonstrates that Oct4 overexpression synergizes with Notch inhibition (Rbpj knockout) to promote the conversion of adult murine Müller glia (MG) into bipolar cells. These findings are ...