综合研究结果和讨论部分，该研究首次揭示了 SYT1 在心脏肥大中的重要保护作用。SYT1 缺乏会通过激活 p38 MAPK 通路，加重压力过载诱导的心脏肥大、纤维化、功能障碍以及心肌细胞凋亡。这一发现为深入理解心脏肥大的发病机制提供了新的视角，也为开发治疗心脏肥大的新策略提供了极具潜力的靶点，有望在未来为心血管疾病的治疗带来新的突破，具有重要的理论和临床意义。

This study presents a valuable finding on the direct cytotoxic effects of DuoHexaBody-CD37 in diffuse large B-cell lymphoma, mediated via SHP-1 activation and antibody clustering, independent of ...

其信号通路主要包括经典的 MAPK/ERK、c-Jun N 端激酶（JNK）、p38 和 ERK5 途径。在乳腺癌中，该通路的异常激活与肿瘤的发生、发展和耐药密切相关。例如，细胞外信号调节激酶 1 和 2（ERK 1/2 ）的异常激活是癌症发生发展的重要驱动因素；JNK 通路参与细胞增殖和 ...

Nat Rev Clin Oncol 18: 345-362. 11. Wu Q, Jiang L, Li SC, et al. (2021): Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway. Acta Pharmacol Sin 42: 1-9. 12. Bai H, Wang Z, Li M, et ...

Hence it is crucial from a therapeutic standpoint to understand the underlying processes and devise countermeasures. This study sought to determine whether the SOCS3/JAK/STAT3 signaling pathway, which ...

The activation of FGFR3–MAPK–STAT signaling pathway has been found to inhibit chondrocyte proliferation and extracellular matrix synthesis in the growth plate, leading to reduced endochondral ...

Department of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Wuhan 430062, China Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research ...

Although the deletion of Shc1 has only a modest impact on lens development and MAPK activity individually, its combination with Frs2 and Shp2 deletion results in a profound arrest of lens vesicle ...

anthracis, proteolytically inactivates MEKs and disables downstream ERK, p38, and JNK pathway signaling leading to ... explore the therapeutic benefit of MAPK pathway reactivation in reversing ...

Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, India 741246 ...