PK/PD analyses of circulating tumor DNA (ctDNA) in patients with metastatic colorectal cancer (mCRC) treated with telisotuzumab adizutecan (ABBV-400). This is an ASCO Meeting Abstract from the 2025 ...

The results highlight an important physiological function of PGAM in the differentiation and suppressive activity of Treg cells by regulating serine synthesis. This role is proposed to intersect with ...

Scientists from A*STAR Genome Institute of Singapore (A*STAR GIS) have uncovered that a key enzyme – P4HA1 prolyl hydroxylase, is strongly induced in CD8+ T cells in solid cancer, the primary ...

Peripheral blood CD4 + /CD8 + ratios at 12 and 24 weeks may serve as predictive markers for HBsAg clearance in IHCs treated with peg-IFN-α. view more Credit: Shuangsuo Dang, Fengping Wu ...

Cancer researchers at the University of Leicester have developed a technique that could predict how well some breast cancer patients will respond to chemotherapy and antibody-directed cancer ...

Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN, United States Foxp3-expressing CD4 regulatory T (Treg) cells play a crucial role in suppressing autoimmunity, tolerating ...

higher proportions of CD28-negative CD8+ T cells (Figure 1A) and higher proportions of CD45RO + T cells in both CD4+ and CD8+ T cells (Figure 1B) (Table 2). Newly diagnosed HT patients showed ...

Tumor infection with MATE-expressing oncolytic adenoviruses leads to T cell activation and tumor immunoactivation in murine tumor models, and results in a CD8-dependent therapeutic benefit.

PBMC were obtained from the peripheral blood, diluted 1:2 in PBS, and separated using a Ficoll-Paque density gradient (Lymphoprep; Alere Technologies). From PBMCs collected from the phase, a portion ...