更进一步的动物实验显示，当将痰湿体质者的菌群移植到小鼠体内时，这些小鼠会发展为肥胖、高脂血症以及脂肪肝，而通过补充Flavonifractor plautii或植物鞘氨醇可有效逆转这些代谢异常。这一研究揭示了植物鞘氨醇可通过激活肝脏PPARα受体，调节脂肪酸的氧化与胆固醇代谢，从而维持全身的代谢稳态。

这项研究为理解痰湿体质为何更易发生代谢紊乱提供了微生物与代谢分子之间的深层关系的新见解，对中医体质理论的现代化具有重要的推动作用。同时，研究还指出，检测Flavonifractor plautii丰度和植物鞘氨醇水平可作为早期预警代谢异常的标志，而开发针对Flavonifractor plautii的益生菌制剂或植物鞘氨醇补充剂，有望成为“治未病”的新战略，展现出广阔的科学价值和应用前景。

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