In particular, most members of the NR2 family are among the least studied proteins of the class, and apart from the retinoid X receptors (RXR), validated NR2 ligands are very rare. Here, we gathered ...

Department of Pharmacy, “Drug Discovery Laboratory”, University of Naples Federico II, via Domenico Montesano 49, I-80131 Naples, Italy ...

Department of Hematology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China Background and purpose: Dyslipidemia has been ...

通过构建基因工程小鼠模型，研究者观察到癌细胞在LGR5+干细胞态与OnF状态之间形成了连续的"表型谱"（phenotypic spectrum）。 在与结直肠癌（colorectal ...

An electronic search through PubMed and Medline up to December 2012 used combinations of the following keywords: 'peroxisome proliferator-activated receptor-α', 'PPAR-α', 'fenofibrate ...

研究显示，APC失活会引发连锁反应： WNT信号通路失控：正常情况下的"刹车"失效，导致干细胞过度增殖 RXR受体失调：调控细胞分化的"守门人"失职 ...

The newly issued senior and mezzanine loans paid off the development’s $102.5 million construction loan that dates to 2022 from Related Fund Management, an affiliate of New York-based Related ...

转录因子足迹分析表明，在肿瘤发生过程中，一些参与建立肠道细胞尾侧身份和成熟的转录因子（如 CDX 和 HNF 家族成员）活性逐渐降低，同时多个配体调节的核受体（如 PPAR、RXR 等）活性也显著下降。相反，肿瘤类器官特异性事件主要由 TCF/LEF、TEADs 和 AP-1 三个 ...

Adult and childhood obesity have reached pandemic level proportions. The idea that caloric excess and insufficient levels of physical activity leads to obesity is a commonly accepted answer for ...

RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARα activation, resulting in ...

Some work as activators, turning genes on, whilst others work as repressors, turning genes off. For example, the transcription factor PPAR alpha is a well-known activator that helps to regulate fat ...