We synthesized a geranyl dimer that binds to the central pocket with micromolar affinity, and dimeric peptides that bind the spike-tip pocket with sub-micromolar affinity. Cryo-electron microscopy ...

The second series deals with peptide-PEG linker-peptide dimers, targeting the tips of HBc dimer spikes. Strengths: This work is very well conducted, combining ITC experiments (for determination of ...

Lip balms and chapsticks have always been skincare staples, but thanks to the rise of peptide lip balms, they've gone from basic hydration heroes to beauty must-haves. Hailey Beiber's launching of the ...

Functional experiments revealed that the enzyme dimer regulates itself through a ... The researchers also discovered the early steps of peptide recognition and hypothesized a set of previously ...

STING agonist-based endoplasmic reticulum-targeting molecules can be conjugated directly onto antigens to deliver them to the cross-presentation pathway, improving CD8 + T cell responses against ...

WPI Nano Life Science Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan ...

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to ...

Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, 94 Weijin Road, Tianjin 300071, China ...

Alzheimer’s disease (AD) is a progressive and devastating neurodegenerative disorder. It is the leading cause of dementia in the world’s rapidly growing aging population. The characteristics of AD are ...