Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia ...

This heightened phosphatase function dephosphorylates the insulin receptor on critical tyrosine residues ... 205 in PTP1B as the principal site phosphorylated by PKA. Mutating this site blocked ...

Solid evidence supports the claim that IKK2 exhibits dual specificity that allows tyrosine autophosphorylation and the authors further show that auto-phosphorylated IKK2 is involved in an ...

69 To confirm that CCL2-mediated AJ disassembly is due to VE-cadherin tyrosine phosphorylation and subsequent dissociation from β-catenin and the actin cytoskeleton and not due to cleavage of the ...

Research Progress of c-Kit in Platinum-Resistant Ovarian Cancer. Journal of Biosciences and Medicines, 13, 404-412. doi: 10.4236/jbm.2025.132030 . According to the date from Chinese Center for Disease ...

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P. R.

Numerous recurrent genetic mutations are known to occur in acute myeloid leukemia (AML). Among these common mutations, Fms-like tyrosine kinase 3 remains as one of the most frequently mutated genes in ...

Although SH2-based far-Western blotting provides a unique insight into overall patterns of binding for different SH2 domains, it is highly dependent on phosphosite abundance, and does not identify ...

These axons form dense perivascular plexuses restricted to striatal regions in rats and monkeys. Interestingly, they are intensely immunoreactive for tyrosine hydroxylase (TH) phosphorylated at Ser19 ...