Adhesion receptors act as molecular fingertips ... Integrin cytoplasmic tyrosine motif is required for outside-in aIIbb3 signalling and platelet function. Nature 401, 808–811 (1999).
Platelets play an important role in atherothrombotic disease. The currently available antiplatelet drugs target key steps of platelet activation including thromboxane A 2 synthesis, ADP-mediated ...