This lack of clear classification, along with insufficient consideration of their role as cells or EVs, contributes to significant gaps in understanding mechanisms regulating platelet biogenesis and ...

A typical platelet count range can change with age. Platelet counts may fluctuate due to natural vascular aging, changes in bone marrow tissue, and altered blood plasma makeup. Platelets ...

Thus, platelets function as one of the important stromal components in the TME, emerging as a promising chemotherapeutic target. However, the use of traditional antiplatelet agents, such as aspirin, ...

Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, 428 Church St., Ann Arbor, Michigan 48109, United States Biointerfaces Institute, NCRC, 2800 Plymouth Rd., Ann Arbor ...

Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Far from being uniform in structure and function, these enzymes display a myriad of distinct mechanistic features. The small number (<100) of DUBs might at first suggest a low degree of ...

Atherosclerotic cardiovascular disease is a major health concern worldwide and requires effective preventive measures. Lp(a) (lipoprotein [a]) has recently garnered attention as an independent risk ...

MPV reflects platelet size and is a marker of platelet function; an elevated MPV has been associated with higher aggregating activity ex vivo. Several studies have reported an increased MPV in other ...

Compared with a placebo injection, platelet-rich plasma injections yielded ... certain changes to their operations or governance structure. According to published results, patients with a history ...

Aims Clopidogrel is the most commonly prescribed thienopyridine as part of dual anti-platelet therapy for the treatment of ...

These obstacles stem from the intra-luminal placement associated with the metallic structure and foreign nature of the FDS ... thus ensuring the maintenance of endothelial main physiological functions ...