Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

Cell cycle re-entry of senescent breast cancer cells after CDK4/6 inhibition (CDK4/6i) constitutes a major source of disease ...

State Key Laboratory of Phytochemistry and Natural Medicines, and Yunnan Characteristic Plant Extraction Laboratory, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article.

Summary: Entrepreneurs often grapple with the decision of whether to structure their business as a Company or a Limited Liability Partnership (LLP). Both offer the advantage of limited liability and ...

Then tumor tissues and cells were lysed in cell lysis buffer (NCM Biotech, WB3100) containing 1% protease and phosphatase inhibitors (NCM Biotech, P002). 10 μg of protein was used to detect the ...

Small molecule inhibition of the PLpro protease domain significantly reduces viral loads in SARS-CoV-2 infection models, suggesting that PLpro is an excellent drug target for next generation ...

We constructed a ZIKVpro expressing vector containing NS2B (residues 45–96) and NS3pro (residues 1-177) linked by a (Gly) 4-Ser-(Gly) 4 sequence, followed by a poly-histidine tag in C-terminal ends, ...