Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein kinase that switches off lipid synthesis. The yeast orthologue, the SNF1 complex, was discovered in screens for mutations ...

One such molecular switch is G protein-coupled receptor kinases ... into a structure resembling a Pac-Man with a ponytail. The kinase domain—the Pac-Man—is the catalytic center where the ...

Delve into the kinase inhibitors' diverse landscape, from cancer breakthroughs to autoimmune disease innovations.

Protein kinase research presents an opportunity to explore molecular targets in the body to treat diseases like cancer and autoimmune disorders. These enzymes have the potential to bind to ...

Wheat is grown over more land area than any other food crop. Among pathogen-driven threats to wheat, fungi top the list, ...

Hangzhou Bio Sincerity Pharmaceutical Technology Co. Ltd. has identified new benzazepinone derivatives acting as receptor-interacting serine/threonine-protein kinase 1 (RIPK1; RIP-1) inhibitors ...

Myasthenia gravis (MG) results from autoimmune antibodies against the post-synaptic neuromuscular junction with three major antibody categories: those to the acetylcholine receptor (AChR antibodies), ...