Although natural sources of compounds that contain the oxazolidin-2-one nucleus are very rare, 5 Kakeya et al. 6 were able to isolate a novel compound belonging to this class, ...

Drug-resistant KB-C2 and SW620/Ad300 cells were incubated with 0.3–5 μM of palbociclib ... and Tyr953 contributed to the stability of the carbonyl group and the amide group of palbociclib and the ...

In September, Akeso, a little-known Chinese biotech company founded nearly a decade ago shook up the biotech sector with its new lung cancer drug. Ivonescimab, the new drug, was found in a trial ...

Terremoto Biosciences Inc. has synthesized new 3H-imidazo[4,5-b]pyridine compounds acting as RAC-α serine/threonine-protein kinase (AKT1; PKB-α) inhibitors reported to be useful for the treatment of ...

BOULDER, Colo.--(BUSINESS WIRE)--#NGS--Watchmaker Genomics, a leading provider of precision tools for genomic research and clinical applications, today announced the successful completion of a key ...

Drug Discovery Lab, Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR 999077, People’s Republic of China Department of Chemistry, National University of ...

Subscribe to the Daily News Brief. Mexican authorities have been waging a deadly battle against drug cartels for nearly two decades, but with limited success. Thousands of Mexicans—including ...

The rate of overdose deaths fell 4% from 2022 to 2023. Rates of drug overdose deaths decreased in the United States for the first time since the COVID-19 pandemic began, according to new federal ...

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So oxetanes and fluorine atoms could be a match made in drug discovery heaven. Researchers also predict that oxetanes decorated with fluorines would have valuable pharmacological properties.

Following this strategy, they determined that the best candidate was a well-designed Fe-SAC with a high loading of Fe-pyridine-N4 sites (~3.83 wt%) and highly mesoporous structure. It successfully ...