HNSCC exhibits diverse tumor microenvironments (TME), influencing progression and therapeutic responses. Pyroptosis, a form of inflammatory programmed cell death may be associated with TME’s and ...

Conclusion: Our study revealed that CLU could ameliorate diabetic atherosclerosis via suppressing inflammatory factors release and pyroptosis of macrophage. CLU may be a promising therapeutic target ...

In essence, the process of pyroptosis is typically initiated through the assembly of inflammasomes, which are critical components of the innate immune system. The activation of these inflammasomes may ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

The release of pro-inflammatory cytokines verified the activation of pyroptosis, enhancing the immune response, while the detection of lipid peroxidation products validated the induction of ...

Research Methodology To explore this phenomenon, the research team utilized artificial intelligence to design modified versions of the HIV protein, enabling them to examine how these changes affected ...

5 Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Singapore 6 Department of Diagnostic Radiology, Singapore General Hospital, Singapore 7 Department of Nuclear ...

a key player in innate immune activation. Together, these effects stimulate a strong anti-tumor immune response, effectively suppressing both melanoma growth and recurrence. Beyond its therapeutic ...

But these immune proteins can do more than that: They also activate other components of ... Older Adults Respond Well to Immunotherapy Despite Age-Related Immune System Differences Apr.