Here, we evaluated combined treatment effectiveness using the apoptosis-sensitive rat insulinoma INS-1 cell lines. DNA laddering, an indicator of camptothecin (CPT)-induced apoptosis, was abolished by ...

RSL3 inhibits selenoenzymes–glutathione peroxidase 4 (GPX4 ... In addition to lipoxygenase, de-repression is observed for Beclin 1, which is directly implicated in autophagy and ferritinophagy. Nrf2 ...

The cGAS-STING signaling pathway-activated mice were used to evaluate the effects of IFNβ on ferroptosis in vivo. HT1080 cells, three-dimensional (3D) spheroids, and the xenograft mouse models were ...

(A-B) Knockdown of SLC7A11 (A) and GPX4 (B) induced increased lipid peroxidation (BODIPY-C11) in JIMT1. (C-D) Treatment with erastin, RSL3 and cysteine starvation for 12 hours induced lipid ...

2012年，Brent Stockwell课题组利用RSL3和erastin两个小分子细胞死亡诱导剂，首次提出并揭示了铁死亡ferroptosis的概念和机制。时至今日，细胞死亡领域已经清晰地意识到，利用化学生物学的方法对死亡诱导剂或抑制剂进行系统性地分析已成为揭示细胞死亡分子机制的 ...

研究人员进一步通过GDSC数据库筛选发现，两种化疗药物（1S,3R）-RSL3和ML-210对高表达PLIN2的OSCC患者具有更高敏感性，这两种药物均为谷胱甘肽过氧化物酶4（GPX4）抑制剂。 本文为澎湃号作者或机构在澎湃新闻上传并发布，仅代表该作者或机构观点，不代表澎湃 ...