Middle molecules with a molecular weight of more than 1,000 are difficult to synthesize due to multiple steps and time-consuming nature, demanding the development of a new approach that can overcome ...

Triple click chemistry has revolutionized chemical synthesis with its simplicity and efficiency, allowing for the quick and selective assembly of complex molecules. Now, in a recent study, researchers ...

By coordinating with alkynes through π-bonding, Lewis π-acids facilitate nucleophilic addition, leading to the formation of alkenyl metal species. These species can undergo electron rearrangement to ...

Department of Medicinal Chemistry, School of Pharmacy, Southwest Medical University, Luzhou 646000, China ...

These reactions can be used for the selective labeling of azide-functionalized biomolecules. The primary advantage of the catalyzed azide-alkyne cycloaddition over the Staudinger ligation is its ...

Middle molecules with a molecular weight of more than 1,000 are difficult to synthesize due to multiple steps and ...

For example, they leveraged the sulfur–fluoride exchange reaction to target the fluorosulfonyl moiety and produce different alcohols in high yields without affecting the azide and alkyne moieties.

In addition to well-known challenges for dicarbofunctionalization of unactivated alkenes, the main obstacles to developing difunctionalization reactions with alcohol as the native directing group ...

A 4.0 magnitude earthquake hit parts of Delhi-NCR early Monday morning, causing tremors in the region. The quake's epicenter was near Durgabai Deshmukh College in Dhaula Kuan, striking at a depth ...