为解决骨质疏松治疗药物存在副作用的问题，研究人员开展了柚皮苷（Naringin）对成骨细胞和小鼠抗骨质疏松机制的研究。结果表明柚皮苷可通过激活 Wnt/β -catenin 通路提升去卵巢（OVX）小鼠骨密度，促进 MC3T3-E1 细胞成骨分化，为新药研发提供理论依据。

钛粒子抑制骨髓间充质干细胞（BMSCs）分化为成骨细胞并下调 Wnt 通路相关因子：茜素红染色和碱性磷酸酶（ALP）染色结果表明，钛粒子处理后，BMSCs 分化为成骨细胞的数量减少。qRT-PCR 分析显示，成骨相关基因（如 Runx2、Ocn 和 Opg）表达水平显著降低。RNA-seq 分析 ...

The mature hypertrophic chondrocytes then express the transcription factor RUNX2 and type X collagen (COL10A1), which are hallmarks of terminal ... chondrocyte differentiation is also modulated by a ...

Shelbourne midfielder Aoibheann Clancy is rewarded for an impressive start to the SSE Airtricity Women’s Premier Division season. The Limerick native earned her only WNT appearance in November 2022.

As the official payment services sponsor of Canada Soccer, Visa is offering cardholders an opportunity to purchase tickets in advance of the public on-sale date. As Canada Soccer’s preferred payment ...

Department of Pediatric Orthopedics, Children’s Hospital Affiliated to Xiangya Medical College of Central South University (Hunan Children’s Hospital), Changsha, 86 Ziyuan Road, Hunan 410000, P. R.

MTT assays measured cell viability, and ALP activity was assessed using a biochemical kit. Western blotting was employed to detect the expression levels of osteoblast-related proteins OCN and RUNX2 ...

Runx2 is expressed in the perimysial populations and CNC-derived progenitor cells during soft palate development To elucidate the dynamic process by which CNC-derived cells differentiate during soft ...

2019). In the present study, we describe a gradient-independent Wnt signaling in instructing stereotyped developmental neurite pruning of the PDB cholinergic motor neuron in C. elegans. From genetic ...