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Histone deacetylase inhibitors (HDACi) are a new class of antineoplastic agents with demonstrable preclinical antitumor activity in both in vitro and in vivo studies in a wide range of malignancies.

Body Dimensions 137.6 x 65.7 x 9.8 mm (5.42 x 2.59 x 0.39 in) ...

Laboratory for Drug Design and Synthesis, Department of Pharmaceutical Sciences and Natural Products, School of Pharmaceutical Sciences, Central University of Punjab, Bathinda 151 401, India ...

We independently review everything we recommend. When you buy through our links, we may earn a commission. Learn more› By Caitlin Giddings and Wirecutter Staff When it comes to gifts, many 1 ...

Myocardial infarction (MI) is accompanied by severe energy deprivation and extensive epigenetic changes. However, how energy metabolism and chromatin modifications are interlinked during MI and heart ...

This manuscript is of particular interest to the community of fungal biologists, along with a broader audience studying epigenetic and protein post-translational modifications. The authors combine ...

Here, we discuss multiple mechanisms underlying hypoxia-induced chemotherapy resistance involving SIRT1-mediated deacetylation modifications of downstream transcription factors and the modulation of ...

Most coronary plaque ruptures/erosions do not lead to ACS. ACS research focuses primarily on vessel breakdown through mechanisms such as inflammation. We have instead proposed that vessel repair ...

Sirt1, the class III histone deacetylase, is generally associated with increased life span and with a pro-survival effect in neurons stressed by pathological factors. Recent work, however, suggests ...