Sirtuin 1 (SirT1) is an essential nutrient-sensing histone deacetylase, which is increased by caloric restriction and reduced by overfeeding. We discovered that SirT1 depletion causes anorexia by ...
This increased the activity of SIRT1, an NAD+-dependent deacetylase, enhancing the deacetylation and activity of PGC-1α.
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