In these catabolic conditions the mitochondrial content, morphology and function are greatly affected. The changes of mitochondrial network influence the production of reactive oxygen species (ROS) ...

Moreover, the potential therapeutic strategies and emerging pharmacological interventions, including immune and metabolic modulators, that show promise in preventing or attenuating cardiac fibrosis ...

35 Table 1. Pathology, Organ Involvement, and Survival in Various Types of Amyloidosis Amyloid deposits in the myocardial interstitium disrupt myocyte function and can lead to diastolic and systolic ...

Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22903, United States ...

1 Department of Health, Human Function, and Rehabilitation Sciences, George Washington University, Washington, DC, USA 2 Department of Physical Medicine and Rehabilitation, Johns Hopkins Hospital, ...

The laminin binding protein dystroglycan plays multiple roles in cell adhesion, signalling and membrane cytoskeleton stability. Perturbation of dystroglycan function underlies several muscular ...

The central governor model has recently been proposed as a general model to explain the phenomenon of fatigue. It proposes that the subconscious brain regulates power output (pacing strategy) by ...

Non-dystrophic myotonias (NDM) are a sub-set of rare (prevalence of 1:100,0004), inherited, myotonic disorders which are caused by mutations within ion channels in the sarcolemma membrane of skeletal ...