Understanding Sickle Cell Anemia and the Need for Early DiagnosisSickle cell anemia is a genetic blood disorder caused by a ...

RTCB is required for the splicing of both tRNA and XBP1 mRNA, whereas the DDX1 enzymatic activity is specifically required for tRNA splicing in vivo. Snaebjornsson et al. explore a selective ...

Background Sickle cell disease (SCD) comprises a heterogeneous group of inherited hemolytic ... 21 Data was retrieved from medical records of all the women referred to the institution for antenatal ...

Patients with diagnosis of SCA confirmed by electrophoresis or HPLC and on steady state were included according ... Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell ...

The tests do not differentiate between those with SCD and those with sickle cell trait (SCT). 3 In hemoglobin electrophoresis, an electric current is used to identify and measure the different types ...

Were included in the study: -Cases: pregnant women suffering from major sickle cell syndrome (SS, SC, Sβ thalassemia), confirmed by hemoglobin electrophoresis, having given birth at the maternity ward ...

A cutting-edge gene therapy has been approved for NHS use for some patients with severe sickle cell disease. Casgevy, also known as exa-cel, was the first treatment to be licensed using gene ...

Sickle cell anaemia, a hereditary condition that primarily affects African and Mediterranean populations, continues to pose significant health challenges. In Uganda, where the disease is prevalent ...

The oral small molecules could induce fetal hemoglobin expression. Other companies have hit on the idea of treating sickle cell by inhibiting BACH1. Mitobridge, which Astellas acquired for $225 ...

Sickle cell anaemia occurs when red blood cells change shape under low oxygen conditions, transforming into a sickle shape that can block blood flow. This blockage can result in pain in the ...