而哮喘只是诸多适应症的一个。其实比较来说，Amlitelimab在特异性皮炎上的临床数据还算不错，最高剂量下，24周时IGA 0/1应答数量百分比达到了45.5%，而24周 EASI-75 ...

Deciphering the gut biome's, including helminths', influence on human trained immunity will unlock novel immunotherapies harnessing the immune reprogramming potential of their secreted factors and ...

BET家族包含BRD2、BRD3、BRD4和BRDT这4种蛋白，它们能够结合特定的表观遗传修饰，调控包括炎症因子在内的多种基因表达。此前的研究发现，BET蛋白对维持多种肿瘤有着重要作用。因此，抑制BET蛋白成为恶性肿瘤的潜在治疗方案。目前已有临床阶段 ...

在癌症免疫中，Th17 细胞作用存在争议且其向 Tregs 转分化机制不明。研究人员开展关于 NLRP3 在 Th17 细胞中作用的研究，发现 NLRP3 影响 Th17 细胞功能，缺乏 NLRP3 可抑制肿瘤生长。该研究为癌症免疫治疗提供新方向。

Gut microbiota composition and sex hormones influence the immune response to methicillin-resistant Staphylococcus aureus gastrointestinal colonization in mice.

细胞因子（cytokine, CK）是一类能在细胞间传递信息、具有免疫调节和效应功能的蛋白质或小分子多肽。通过调节免疫细胞的行为， 细胞因子在维持免 疫平衡、抵御传染源和疾病方面发挥着重要作用。细胞因子的主要类型包括：白介素 (IL)：IL-1, IL-2, IL-6, IL-8, IL-10 ...

Jeff Jones; Analyst; Oppenheimer & Co., Inc. Aydin Huseynov; Analyst; Ladenburg Thalmann & Co. Inc. Good afternoon, everyone. Thank you for standing by and welcome to the Corvus Pharmaceuticals ...

The data also highlights its mechanism of action, skewing differentiation to Th1 cells, reducing Th2 and Th17 cells and their downstream cytokines, and promoting a switch to T regulatory cells ...

1 State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical ...

Most often the malignant cells of PTCL express a Th2 phenotype. Corvus Pharmaceuticals is a clinical-stage biopharmaceutical company pioneering the development of ITK inhibition as a new approach to ...