Cells and gene products potentially involved in the pathogenesis of RA and SLE are, therefore, also operative in the pathogenesis of atherosclerosis. Considerable evidence suggests that the ...

Advances in knowledge about the pathogenesis of rheumatoid arthritis (RA) have led to the development of targeted therapies that act directly on inflammatory cytokines or cell-surface molecules.

To gain a clearer understanding of CII's role in the pathogenesis of RA, researchers at Queen Mary, University of London and others studied its behavior within an inflamed joint, when modified by ...

Rheumatoid arthritis (RA) is an autoimmune disease that causes joint inflammation and destruction. There is currently no cure—and although there are many treatments, their effectiveness varies ...

Inhibition of c-kit with imatinib or other small-molecule tyrosine kinase inhibitors could provide benefit in patients with inflammatory diseases in which mast cells contribute to pathogenesis.

Rheumatoid arthritis (RA) and lupus both cause joint pain and stiffness. Despite some similarities, it’s easy for doctors to distinguish them. RA has more debilitating effects on the joints.

Microglia are brain-resident macrophages playing pivotal roles in CNS development and homeostasis. Yet, the cellular and molecular basis governing microglia maintenance ...