Models were fitted to population data using NMQUAL (https://metruminstitute.org/index.html-validated installation of the NONMEM, version V, level 1.1; GloboMax ...

The parameter and OBJs values for the base 1-, 2-, and 3-compartment models are summarized in Table 1. As found in the separate modeling of the intravenous and nasal data, the 2-compartment model ...

Voriconazole pharmacokinetics was best described by one-compartment PK model with first-order absorption, parameterized by clearance of 4.56 L/h (36.9% CV), volume of distribution of 60.7 L, ...

The primary endpoint was to evaluate the safety, tolerability, and pharmacokinetic (PK) profiles of a subcutaneous ... simulations were performed to guide the AK111 dose selection for phase 2/3 trials ...

Mydriatic microdrops are noninferior to standard drops of a diluted mydriatic mixture when used in infants being screened for ROP.

The long-awaited Grok-3 has been spotted in the wild. Although this model is not yet available to the public, we managed to access it on the stand-alone Grok platform. We were also able to compare the ...

Daniel Robinson is a writer based in Greenville, N.C. with expertise in auto insurance, loans, warranty options and more. Away from the keyboard, Daniel spends time with his wife and son, plays ...

Is the Tesla Model 3 a good car? The Tesla Model 3 is one of the best electric cars around. It’s practical, high-tech, and boasts great performance and range for a competitive price. The all ...

Tesla has built a reputation for making cars that accelerate quicker than just about anything else on the road, and the Model 3 does exactly that, with even the entry-level, rear-drive ...

The importance of pharmacokinetic (PK) and pharmacodynamic (PD ... affecting the design and conduct of paediatric pharmacological studies can be overcome using targeted pharmacometric strategies.

The Tesla Model 3 and Model Y have consistently ranked among the best-selling cars in the UK for years, with the Model Y the UK’s favourite new electric car for the past two years. However ...