We show here that these diverse peptide sequences bind with comparable affinities to the Numb PTB domain at a common binding site on the surface of the protein. The NMR structure of the Numb PTB ...

As the steward of the UB campus network ... a recognized support structure in place New sub-domains of buffalo.edu must contain a reasonable number of hostnames to substantiate a separate name space ...

Search for other works by this author on: ...

Department of Structural Biology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York 14203, United States ...

Search for other works by this author on: ...

In addition, when performing multibit computations, nonlinearity errors between different bits can adversely affect the network’s accuracy. Therefore, this work proposes an 8Kb dual-edge time-domain ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.

Boosting ligand-protein binding affinity in Structure-based Drug Design (SBDD) with a single energy gradient term! Excited to share our recent preprint on Diffusion Guidance for Structure-based ...

Separate the detailed implementation area and the domain area. The architecture does not depend on the framework. The outer layers can depend on the inner layers, but the inner layers cannot depend on ...

The authors of the current study previously designed a covalent PL pro inhibitor Jun11313 that bound to the Val70 Ub binding site ... the naphthalene-based structure was replaced with quinoline ...