类风湿关节炎(RA)中成纤维样滑膜细胞(FLSs)异常增殖是关节破坏的关键因素。研究人员发现姜黄素光动力疗法(CUR-PDT)通过下调 ...

儿茶素减轻 APAP 诱导的肝细胞铁死亡：检测铁死亡相关指标发现，儿茶素能逆转 APAP 诱导的前列腺素内过氧化物合酶 2（Ptgs2）水平的升高，增加谷胱甘肽过氧化物酶 4（GPX4）和胱氨酸 / 谷氨酸逆向转运体（xCT）的表达，降低肝细胞内 Fe 2+ 的积累。使用铁死亡 ...

Three key cellular enzymatic antioxidants such as glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1), and dihydroorotate dehydrogenase (DHODH), have been elucidated as crucial ...

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Collectively, these results indicate that impairment of the GPX4-GSH pathway is a critical driver of ferroptosis in various HLIs and a potential common therapeutic target. Although cathelicidin shows ...

The schematic below shows the process of generating 3D, volumetric images using X-ray computed tomography (XCT). XCT is based on taking 2D ragiographs through a sample at many projections around the ...

在细胞的生理状态下，System XC⁻是细胞内重要的氨基酸转运系统，由溶质转运家族成员SLC7A11（又称为xCT）和SLC3A2组成 ... 其中最为关键的是作为谷胱甘肽过氧化物酶4（GPX4）的必要辅因子。在氧化应激条件下，GSH能够将还原型GSH转化为氧化型GSH，同时将脂质 ...

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