Host cells activate cell death pathways in response to bacterial manipulation of innate immune signalling, but the molecular mechanisms underlying this interplay are not fully understood. This study ...

The body instinctively responds to external stimuli by increasing energy metabolism and initiating immune responses upon receiving stress signals. Corticosterone (CORT), a glucocorticoid (GC) that ...

Initially, the various programmed death mechanisms were considered to be mutually independent, however, this perspective was challenged by the investigation of PANoptosis, which involves TNF-α and IFN ...

其他 DNA 传感器：IFI16 和 DDX41 等也参与 DNA 感应过程，它们与 STING 相互作用，增强 I 型 IFN 反应和 NF-κB 激活。Z-DNA 结合蛋白 1（ZBP1）能诱导 TBK1-IRF3-IFN I 和 NF-κB 信号通路，促进炎性小体激活和细胞死亡。此外，还有一些 DNA 结合蛋白与 DNA 诱导的 IFN 产生相关 ...

本文聚焦胃癌（GC），深入剖析 Toll 样受体（TLR）家族在其中的多种作用，极具科研价值。 Toll 样受体（TLR）家族在胃癌（GC）中的多重作用 胃癌（Gastric cancer，GC）作为一种严重威胁人类健康的恶性肿瘤，其发生发展是一个极为复杂的过程。众多因素相互交织 ...