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Nature:蛋白质聚集在自闭症相关基因的“主调节器”上
这种名为CPEB4的调节因子通常控制着数百种自闭症相关基因的蛋白质产生,但在自闭症患者身上发现的另一种CPEB4会形成不可逆的团块和功能障碍。 一项新的研究表明,CPEB4蛋白控制着数百个自闭症相关基因,但在一些自闭症患者的大脑中发现的另一种CPEB4蛋白会形成不可逆的团块,无法正常工作。 CPEB4帮助将信使RNA翻译成蛋白质。在一些自闭症患者身上看到的版本缺少一个称为microexon 4的片 ...
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