Paget’s disease of the bone (osteitis deformans) is a chronic bone disorder characterized by excessive breakdown and regrowth in the affected bone(s). Many people have no symptoms. The disease is more common as you age and is uncommon in people under the age of 50.

2023年1月11日 · Paget's (PAJ-its) disease of bone interferes with your body's normal recycling process, in which new bone tissue gradually replaces old bone tissue. Over time, bones can become fragile and misshapen. The pelvis, skull, spine and legs are most commonly affected.

Paget's disease of bone (commonly known as Paget's disease or, historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. The affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone ...

In most cases, treatment for Paget’s disease involves taking medications to help slow or stop the progress of the disease. For patients who have complications, surgery may be needed to realign deformed bones or to help fractures heal. Paget's disease can affect any bone in the skeleton.

Paget disease of the bone is a chronic bone disorder. It causes bones to become enlarged and deformed. Bone may become dense, but fragile, because of excessive breakdown and deformation of bone. The disease is the most common bone disorder after osteoporosis in adults older than age 50. What causes Paget disease of the bone?

2024年3月25日 · Paget's disease of bone is a chronic bone disorder. Normally, there is a process in which your bones break down and then regrow. In Paget's disease, this process is abnormal. There is excessive breakdown and regrowth of bone. Because the bones regrow too quickly, they are bigger and softer than normal.

Paget's disease of bone (PDB), which is also known as osteitis deformans, was first described by Sir James Paget more than 130 years ago [Paget, 1877]. Paget's disease is a common focal skeletal disorder that may involve a single bone (monostotic) or multiple bones (polyos-totic).

2019年8月22日 · Paget disease of bone is a chronic disorder of the adult skeleton in which bone turnover is accelerated in localized areas. Normal matrix is replaced with softened and enlarged bone. The disease may be asymptomatic or cause gradual onset of bone pain or deformity. Diagnosis is by x-ray.

Paget's disease, also known as osteitis deformans, is a chronic bone disorder. It generally affects the growth of new bone in adults, and it leads to the formation of abnormally large, weak bones that break easily.

2025年1月22日 · Paget disease of bone is a disorder of an aging skeleton in which some bones grow abnormally, affecting their size and shape. This can sometimes lead to pain in the bone and the nearby joints.