The aim of this study is to provide a 4-step guideline for inducing a rat model of osteoporosis by ovariectomy (OVX): (1) selection of the rat strain, (2) choosing the appropriate age of rats at the time of OVX, (3) selection of an appropriate surgical method and verification of OVX, and (4) evaluation of OVX-induced osteoporosis.

Ovariectomized (OVX) animal is a typical experimental model for investigation of postmenopausal osteoporosis due to estrogen deficiency in women. Recently, both OVX mouse and OVX rat are commonly used for the evaluation of bone tissues in the animal model.

2021年6月1日 · Our study showed clear differences in the bone repair process between metaphysis and diaphysis using OVX mouse model. The bone repair processes in both the sites were delayed in the OVX model compared to that in Sham group.

2017年9月14日 · Here, using a mouse model mimicking estrogen deficiency-induced bone loss combined with longitudinal in vivo micro-CT, we investigated bone formation, bone resorption, and the consequent architectural modifications around the implant and in the whole implanted bone for 6 weeks following implantation.

2011年6月1日 · The bone healing of the drill-hole defect was impaired in mice with OVX-induced osteoporosis. The present study provides a model to investigate the functional role of specific gene in osteoporotic bone healing and may facilitate development of novel therapeutic strategies for promoting osteoporotic …

2018年12月1日 · We compared the activity of differentially expressed genes of osteoblasts in ovariectomized mice that undertook exercise (OVX+T) with those that did not (OVX), using microarray and bioinformatics. Many inflammatory pathways were significantly downregulated in the osteoblasts after exercise.

Biocytogen has established an ovariectomy (OVX) model in both mice and rats, in which bone density and other metrics can be measured to monitor disease onset and the impact of treatment interventions.

2011年1月1日 · OVX rats are used as animal models to determine the therapeutic effects for the prevention and treatment of osteoporosis. Several compounds including hormones and combinations of hormones with other compounds have also been studied in the OVX rats and mice models for osteoporosis.

2018年11月7日 · In this study, bilateral ovariectomy was performed to establish an OVX mouse model of osteoporosis. UPLC-Q-TOF-MS-based lipidomics in combination with metabolomics were used to analyze the femur...

2019年10月1日 · Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common model for osteoporosis. However, a comprehensive in vivo assessment of intervention-related changes in multiple bone properties, and in multiple mouse strains, is required in order to identify an appropriate model for future evaluation of novel anti ...