p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]

1995年7月11日 · Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations in human cancer. The majority of the mutations occur in the core domain which contains the sequence-specific DNA binding activity of the p53 protein (residues 102-292), and they result in loss of DNA binding.

The gene encoding the p53 tumor suppressor protein, a sequence-specific DNA binding transcription factor, is the most frequently mutated gene in human cancer. Crystal structures of homo-oligomerizing p53 polypeptides with specific DNA suggest that DNA binding is associated with a conformational switch.

p53 tumor suppressor is a flexible molecule composed of four identical protein chains. Flexible molecules are difficult to study by x-ray crystallography because they do not form orderly crystals, and if they do crystallize, the experimental images are often blurry.

1999年9月15日 · Like many transcription factors, p53-like proteins are modular molecules with a conserved transcriptional activation domain, DNA-binding domain and an oligomerization domain that mediates...

2023年3月1日 · For the first time, a Penn State-led team of researchers uncovered the complete structure of the p53 protein using patient samples. They also investigated how mutation-induced changes in the p53 structure can impact different cancers.

P53 Protein Domain Structure A. The 393-amino acid residue p53 protein comprises an amino-terminus transactivation domain (blue), followed by a proline-rich region (purple), a central DNA-binding core domain (green), a tetramerization domain (pink) and a regulatory domain (yellow) at the carboxyl-terminus. B. For more about p53 mutations, see ...

1996年10月16日 · The p53 tumor suppressor protein is involved in multiple central cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle control, and apoptosis. p53 is functionally inactivated by structural mutations, interaction with viral products, and endogenous cellular mechanisms in the majority of human cancers.

The tumor suppressor protein p53, known as "the guardian of the genome," protects the body's DNA from daily stress or long-term damage by triggering the cells to make repairs or to...

As described in this chapter, significant progress has been made towards understanding its three-dimensional structure. The structural information has helped our understanding of p53 function and regulation and has also explained how tumor-associated mutations inactivate p53.