2018年4月21日 · The autoimmune cause of this class of blistering skin conditions is confirmed by positive direct immunofluorescence microscopy revealing the deposition of antibodies in the skin. Pemphigus The main types of pemphigus are pemphigus vulgaris , pemphigus foliaceus , and paraneoplastic pemphigus [9].

A to Z directory of skin diseases, conditions, and their treatments from DermNet.

What is an inflammatory skin disease? Inflammatory skin diseases are characterised by the activation of the innate and adaptive immune system via the production of pro-inflammatory cytokines [4]. They are classified as autoimmune diseases …

Diagnosis of chronic blistering diseases often requires skin biopsy for histopathology and direct immunofluorescence. A blood test for specific antibodies ( indirect immunofluorescence ) may also prove helpful in making the diagnosis of an immunobullous disease.

Direct immunofluorescence for the diagnosis of skin diseases. DIF is useful in the diagnosis of suspected autoimmune disease, connective tissue diseases and vasculitis. The staining patterns seen in tissue samples may be specific to a disease entity or they may need to be interpreted with the clinical and histological findings.

Autoinflammatory syndromes may be inherited through mutations to a single gene (monogenic autoinflammatory syndromes), or, more commonly, are polygenic immune conditions that resemble autoimmune collagen disorders. The number of conditions included is increasing as molecular and genetic studies reveal disease mechanisms.

Diabetic dermopathy is a skin condition characterised by light brown or reddish, oval or round, slightly indented scaly patches most often appearing on the shins. Although these lesions may appear in anyone, particularly after an injury or trauma to the area, they are one of the most common skin problems found in patients with diabetes mellitus.

The autoimmune antibodies can also be detected by a skin antibody blood test (indirect immunofluorescence). It is positive in 80-90% of patients with active pemphigus. Disease activity correlates with antibody titre (concentration) in most patients. Treatment of pemphigus. In the past, pemphigus has been associated with high mortality and ...

Many autoimmune connective tissue diseases and vascular conditions in rheumatology have cutaneous manifestations. Skin signs are useful in the diagnosis of rheumatic disease, as they often precede systemic symptoms. They can also act as a prognostic marker and predict systemic involvement. Rheumatic diseases described on this page are:

Skin signs of chronic viral hepatitis. At least 20% of patients with chronic hepatitis due to HBV or HCV develop skin changes, only a few of which are diagnostic of viral hepatitis. Skin conditions associated with both HBV and HCV. Cryoglobulinaemia types II and III (mixed) — can present with skin signs of cutaneous vasculitis or systemic ...