2019年11月13日 · The quality of the BM smear was defined in any of the following: aspicular (without spicules), pauciaspicular (1-3 spicules), spicular (> 3 spicules), defining aspicular BM smear as non-diagnostic samples.

Bone marrow aspiration is performed to assess cellular morphology and to conduct tests on the bone marrow. Bone marrow biopsy is often performed in tandem to provide information about the...

Bone marrow aspirates should be examined immediately for the presence of spicules; these small fragments of bone indicate that the marrow cavity has been accessed and that the aspiration has been performed correctly.

2024年1月12日 · Bone marrow aspirate and cytology. Aspirate biopsy is a relatively easy and fast method for evaluating bone marrow. With diagnostic quality aspirates that contain sufficient bone marrow spicules, estimation of bone marrow cellularity is fairly accurate.

How do the different parts of a “bone marrow workup” relate to more in-depth analyses of morphology, markers, lineages, and overall diagnostic information? Why do some investigations yield more, or less, information than others? What is the hematopathologist looking for when assembling all the parts to report back in consultation with you?

Bone marrow evaluation includes an assessment of the following: An estimate of cellularity, evaluation of all hematopoietic lineages (including an M:E ratio), estimation of iron stores, and an assessment of other cell types.

• In general, a bone marrow study is composed of the following complementary components: – Peripheral blood – Aspirate smear/touch preparations – Core biopsy • The three hematopoietic lineages are myeloids, erythroids, and megakaryocytes • Knowledge of normal marrow morphology, distribution, and maturational sequence is

2009年10月8日 · Bone marrow aspiration is performed to obtain specimens used to assess cellular morphology and to conduct specialized tests on the bone marrow, such as flow cytometry for immunophenotypic...

Histopathology can reveal bone marrow architecture, general cellularity, megakaryocyte numbers and shape, a myeloid to erythroid ratio estimate, and iron storage, as well as show focal or mild lesions.

• Obtaining spicules (bone marrow particles rich in hematopoietic elements) on the first pull of the aspiration may be easier using a larger syringe (30 or 60 mL). • Aspirating more than 0.25 mL of marrow initially dilutes the sample with sinusoidal blood and interferes with morphologic studies.