Brodifacoum is a rodenticide that interferes with the production of vitamin K-dependent coagulation factors, leading to prolonged periods of anticoagulation and increased bleeding time. Treatment involves replacing clotting factors and administering vitamin K. AI generated definition based on: Encyclopedia of Toxicology (Third Edition), 2014

Typically, however, while brodifacoum is highly toxic to aquatic organisms, not enough brodifacoum will dissolve in water to cause harm to animals not specifically targeted. At a 10 mg l −1 dose of brodifacoum, there is no difference in the growing rate of algae and with a concentrate of 0.25% at 10 mg l −1 the Cl 50 is 10 mg l −1 for ...

Brodifacoum undergoes enterohepatic recirculation and animals poisoned by these pesticides will likely benefit from multiple activated charcoal doses to enhance elimination. The toxicity of zinc phosphide results from the phosphine gas, which is produced by …

2017年2月15日 · Because of the commercial availability of brodifacoum, the variety of routes with which individuals can be exposed to drug, and the delayed manifestations of symptoms after poisoning, the US government lists brodifacoum on the chemical threat risk assessment compound list.15 Brodifacoum consists of a substituted phenyl chain for the terminal ...

Brodifacoum was detected in the blood at a level of 0.002 ppm. The bird was treated with injectable and oral vitamin K 1 and transfused with 40 ml of whole blood and fully recovered (James et al., 1995). Absorption, Distribution, Metabolism, and Excretion. Brodifacoum is absorbed through the gastrointestinal tract. When orally administered to ...

2017年2月15日 · Amongst the superwarfarins typically incorporated into rodent bait, brodifacoum (BDF) is the most widely used. Poisoning by ingestion, inhalation or absorption through the skin of BDF shows no signs or symptoms in humans other than delayed (after several days) development of severe, long-lasting (up to months) bleeding events.

2025年1月1日 · Brodifacoum-exposed fish showed dose-dependent typical symptoms of an intoxication with ARs such as prolonged clotting times, hemorrhages, discoloration, anemia, lethargy, and anorexia (Rattner et al., 2014b, Scott and Sloman, 2004, Valchev et al., 2008, Webster et al., 2015). Coagulation times were assessed with a method developed for human ...

2023年4月1日 · The limit of detection was 0.23–0.28 ng/mL (ng/g) for bromadiolone and 0.34–0.61 ng/mL (ng/g) for brodifacoum in corn and human serum, with recovery ratios higher than 82.3 %. These satisfactory results illustrated our proposed assay was a potential tool for food analysis and poisoning diagnosis caused by bromadiolone and brodifacoum.

2018年12月1日 · The brodifacoum no-choice feeding test was conducted according to procedures described by Redfern et al. (1976). Brodifacoum bait was offered in separate no-choice trials over 24 or 48 h feeding periods. Each test included 10 animals (5 males and 5 females) that survived the bromadiolone test. Bait consumption was measured daily.

2016年10月1日 · Brodifacoum poisoning was confirmed since all of the blood samples collected from treatment groups were tested positive for brodifacoum. The blood brodifacoum concentration in the low-dose, middle-dose, and high-dose groups were 0.6 ± 0.2 ng/mL, 3.7 ± 1.2 ng/mL, and 7.4 ± 2.6 ng/mL, respectively. Thus, the blood brodifacoum concentration was ...