Calcium pumps are a family of ion transporters found in the cell membrane of all animal cells. They are responsible for the active transport of calcium out of the cell for the maintenance of the steep Ca 2+ electrochemical gradient across the cell membrane.

The calcium pump allows muscles to relax after this frenzied wave of calcium-induced contraction. The pump is found in the membrane of the sarcoplasmic reticulum. In some cases, it is so plentiful that it may make up 90% of the protein there. Powered by ATP, it pumps calcium ions back into the sarcoplasmic reticulum, reducing the calcium level ...

‌Ca泵，也称为钙离子泵（Ca2+-ATP酶），是存在于组织细胞及细胞器的膜上的一种蛋白酶。 它催化质膜内侧的ATP水解，释放出能量，驱动细胞内的钙离子泵出细胞或者泵入内质网腔中储存起来，以维持细胞内低浓度的游离Ca2+。 由于其活性依赖于ATP与Mg2+的结合，所以又称为 (Ca2+，Mg2+)-ATP酶。 Ca2+-Mg2+-ATP酶（即 钙泵）是存在于 组织细胞 及 细胞器 的膜上的一种 蛋白酶，由于其离子运转是借助类似泵的机制来完成的，医学上将离子的这种运转方式称 …

There are no large channels leading from the cytoplasmic surface to the pair of high-affinity Ca (2+) binding sites within the transmembrane region. One possible access pathway involves the charged residues in transmembrane alpha-helix M1, with a Ca (2+) ion passing through the first site to reach the second site.

2022年1月18日 · In this review, I summarize the present knowledge of the structural and functional properties of the mammalian plasma membrane calcium pump (PMCA). It is outlined how the cellular expression of the different spliced isoforms of the four genes are regulated under normal and pathological conditions.

The calcium pump, also known as the calcium-ATPase or sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), is an integral membrane protein that actively transports calcium ions (Ca2+) from the cytoplasm of a cell into the lumen of the endoplasmic reticulum or …

2025年1月6日 · Cell - Calcium Pumps, Membrane Transport, Homeostasis: Many animal cells can perform a primary active transport of calcium out of the cell, developing a 10,000-fold gradient of that ion. Calcium-activated ATPases have been isolated and shown to be intrinsic proteins straddling the membrane and undergoing conformational changes similar to those ...

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are thus essential to the correct functioning of the cell machinery. They have high affinity for Ca2+ and can efficiently regulate it down to very low concentration levels. Two …

2000年4月1日 · Eukaryotic cells remove calcium from the cytosol using P-type pumps in the plasma membrane and in the sarco (endo)plasmic reticulum. These pumps share membrane topography and general mechanism of action, but differ in regulatory properties.

2017年11月8日 · 钙泵（calcium pump）在每个方向仅长几个纳米，并且存在于细胞膜中。 不过，尽管它的尺寸很小，但它对生命是必不可少的。 钙泵是我们的肌肉能够收缩和神经元能够发送信号的原因。