2024年7月5日 · Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor...

The theory of cancer stem cells states that a given subgroup of cancer cells drives tumor spread and growth which causes the progeny of cancer cells to be highly differentiated and destined to cease the proliferation because they have restricted mitotic divisions.

Cancer stem cells (CSCs) are cancer cells (found within tumors or hematological cancers) that possess characteristics associated with normal stem cells, specifically the ability to give rise to all cell types found in a particular cancer sample.

Lurking somewhere within every tumor, some say, are a few stem cells that have lost their genetic marbles, so to speak - continuously supplying a malignant mass with cancerous cells. Stem cells are key to our normal development and health from conception through adulthood.

Cancer stem cells (CSCs) represent a small subpopulation of cells within a tumor that express cell surface markers including CD44, CD24 and/or CD133. CSCs are capable of self-renewal and differentiation into non-tumorigenic cell progeny.

The stem cell theory of cancer proposes that among the many different types of cells within a cancer, there exists a subpopulation of cells called cancer stem cells that multiply indefinitely, are resistant to chemotherapy, and are thought to be responsible for relapse after therapy.

Cancer stem cells (CSCs) describe a class of pluripotent cancer cells that behave analogously to normal stem cells in their ability to differentiate into the spectrum of cell types observed in tumors.

Normal stem cells have unique properties that could contribute to cancer development. First, they are often the only long-lived cells in a tissue that have the ability to re-initiate cell replication and thus have the time to accumulate genetic mutations [5].

2019年6月5日 · Therapeutic agents must target both quiescent and proliferating cancer stem cells, cancer stem-cell populations arising from specific mutations, and cells that have acquired mutations...

2024年5月2日 · Cancer stemness, regarded as a crucial factor in tumor development, has been recognized to involve a plastic cellular state influenced by dynamic interactions between cancer stem cells (CSCs) and their niche. Herein, we provide a summary of the defining and emerging hallmarks of CSCs and/or cancer stemness.