Within the field of developmental biology, one goal is to understand how a particular cell develops into a final cell type, known as fate determination. Within an embryo, several processes play …

2024年5月6日 · Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among molecules, making …

Cell fate is determined through a coordinated activity of transcription factors (TFs) and chromatin-remodeling complexes that establish a chromatin landscape that defines the gene products …

2025年1月15日 · The fate of a cell describes its future identity, or the identity of its daughter cells, before it is actually phenotypically detectable through differentiation or division.

We will briefly introduce some notions from dynamical systems theory, and discuss how they offer a framework within which to build a rigorous understanding of what we mean by a cell “fate”, …

Cells must “decide” whether to replicate, differentiate, or die. These cellular decisions are a critical aspect of organismal development, wound healing, and immune systems. However, cells may …

The choice of a cell's fate affects all aspects of its behavior, defining a cell's morphology, migratory status, and proliferation and the competence to do a range of specific functions …

2022年11月23日 · We introduce quantitative fate mapping, an approach to reconstruct the hierarchy, commitment times, population sizes, and commitment biases of intermediate …

2025年1月30日 · Cochlear inner hair cells (IHCs) and outer hair cells (OHCs) require different transcription factors for their cell fate stabilization and survival, suggesting separate …

2023年12月29日 · While major advances in cell fate theory have been achieved by these mechanism-focused frameworks, there are some aspects of cell decision-making that require …

This review highlights how alternative splicing (AS) shapes cell fate, covering its regulatory impact on proliferation, cell cycle, differentiation, apoptosis, and oncogenesis.

2019年4月8日 · How organ morphogenesis specifies cell fate and whether organ progenitors are predetermined or specified via niche signals are critical developmental biology questions.

2019年6月7日 · One of the most intriguing conclusions from Soldatov et al. is the identification of specific steps involved in neural crest differentiation, in which progenitor cells undergo binary …

Cell fate refers to the process that determines how many times a cell divides, influenced by stem cells, precursor cells, cell cycle exit, and apoptosis. It is regulated by cell fate determining …

6 天之前 · Viscoelasticity is the mechanical feature of living tissues and the cellular extracellular matrix (ECM) and has been recognized as an essential biophysical cue in cell function and …

In this review, we discuss recent advances in understanding the role of metabolism, reactive oxygen species (ROS), intracellular pH (pHi), and cell morphology and adhesions to cell fate …

2024年5月6日 · Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among molecules, making …

We will briefly introduce some notions from dynamical systems theory, and discuss how they offer a framework within which to build a rigorous understanding of what we mean by a cell "fate", …

Cell fate specification refers to the process by which an undifferentiated cell becomes committed to developing into a specific type of cell with a particular function or role in the body. During …

3 天之前 · Oh, S. et al. Stem cell fate dictated solely by altered nanotube dimension. PNAS 106 , 2130–2135 (2009). Article ADS CAS PubMed PubMed Central MATH Google Scholar

2024年5月1日 · Abstract. T cell exhaustion, a state of T cell dysfunctionality is well defined in chronic viral infections, however, not completely understood in tumor se ... Haiguang Wang, …

2017年10月13日 · The choice of a cell's fate affects all aspects of its behavior, defining a cell's morphology, migratory status, and proliferation and the competence to do a range of specific …

Cellular differentiation is a common underlying feature of all multicellular organisms through which naïve cells progressively become fate restricted and develop into mature cells with specialized …

3 天之前 · An artist's impression of cancer cells. peterschreiber.media/iStock / Getty Images Plus. A critical transition, the researchers explain, is when a radical change in state occurs at a …

2022年1月19日 · Recent work shows how molecular “noise” can shape the architecture of this landscape and how universal properties of cell fate commitment can be distilled from careful …

5 天之前 · Over the past few decades, MSCs have emerged as the most clinically studied experimental cell therapy, with significant advances achieved in their development as a …

4 天之前 · In turn, these specially designed stem cells can produce all kinds of human cells, including T and NK cells. Additionally, FATE combines those capabilities with CRISPR and …