2023年3月28日 · AD-related endothelial transcriptomic changes also increased along the Braak stage continuum but showed limited overlap with region-specific genes. Analysis of how endothelial cell genes associate with AD pathological burden revealed six overall trends suggestive of distinct temporal relationships with AD disease progression.

2020年10月22日 · Endothelial cells tend to get short shrift in studies of Alzheimer’s, but new results now implicate these cells in the toxic brain environment of people with this disease. In the September 28 Proceedings of the National Academy of Sciences, researchers led by Nancy Ip at the Hong Kong University of Science and Technology analyzed a large ...

2023年6月22日 · Capillary endothelial cells, the majority of endothelial cells (ECs) in the brain, showed the highest number of differentially expressed genes (DEGs) in AD, which included cell junction and adhesion-associated genes as well as genes involved in BBB transport. DEGs in arterial ECs included tight junction components.

2021年5月9日 · Betsholtz reported a gradual shift in the expression profile of endothelial cells along the arteriovenous continuum, i.e., the progression of the vasculature from arteries to capillaries to veins. By contrast, the delineations between different smooth muscle cell (SMC) and pericyte populations were sharp (Vanlandewijck et al., 2018).

2020年6月15日 · The full complexity of the blood-brain barrier, with its different cell types acting together, has been difficult to model in vitro. In the June 8 Nature Medicine, researchers led by Li-Huei Tsai at the Massachusetts Institute of Technology, Cambridge, debuted a model that combined endothelial cells, astrocytes, and pericyte-like cells in a ...

2021年10月28日 · In vitro, the viral protease cleaved NF-κB essential modulator. NEMO, a transcription factor, triggers host antiviral responses and prevents endothelial cell death. Without NEMO, endothelial cells perished by necroptosis. In NEMO knockout mice, inhibiting the necroptotic kinase RIPK3 preserved brain blood vessels and BBB integrity. Though ...

2020年7月17日 · Alpl encodes the brain endothelial cell surface alkaline phosphatase ALPL. Yang et al. took advantage of a previously identified, commercially available small molecule inhibitor of ALPL to show that ALPL inhibition in aged mice was capable of significantly increasing brain uptake of circulating Tf and labeled plasma and, to a lesser degree, a ...

2015年6月23日 · The group previously reported that extracellular Aβ must bind to the low-density lipoprotein receptor related protein 1 (LRP1) on brain capillary endothelial cells to be transported through the cell to the bloodstream (see Deane et al., 2004). In the present study, the authors found that PICALM fastened onto the Aβ/LRP1 complex within 30 ...

2019年11月15日 · Axel Montagne University of Edinburgh; Posted: 15 Nov 2019 This is a noteworthy study by the Daneman lab comparing the transcriptional profiles of mouse blood-brain barrier (BBB) endothelial cells (ECs) with those in other organs of the body (i.e., heart, lung, kidney, and liver) using RNA-Seq method and an inducible endothelial-specific reporter mouse …

2022年4月9日 · Cell-Cell Cross Talk Resilience emerged as an important cellular state in Albanus’s analysis. He also used snRNA-Seq data, this time from parietal cortex tissue donated by 67 people who had either been in the DIAN study of autosomal-dominant AD, or had been treated at the Knight Alzheimer’s Disease Research Center at WashU.