G-quadruplex forming sequences are prevalent in eukaryotic cells, especially in telomeres, 5` untranslated strands, and translocation hot spots. G-quadruplexes can inhibit normal cell function, and in healthy cells, are easily and readily unwound by helicase. However, in cancer cells that have mutated helicase these complexes cannot be unwound ...

2020年4月20日 · DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4) structures form through self-recognition of guanines into stacked tetrads, and considerable biophysical and...

2020年2月1日 · One such class of DNA secondary structure is the four-stranded G-quadruplex (G4). Herein, we discuss some of the key scientific history that has shaped our understanding of this structural motif, its probable functions in biology, and major unanswered questions that remain to be solved.

2012年10月3日 · G-quadruplex (G4) DNA is a stable secondary structure held together by G-G base pairs. DNA sequences capable of forming G4 DNA in vitro (G4 motifs) are enriched in ribosomal DNA and...

G-quadruplexes or G4s are non-canonical secondary structures of nucleic acids characterized by guanines arranged in stacked tetraplex arrays.

2017年2月22日 · Single-stranded guanine-rich DNA sequences can fold into stable intramolecular and intermolecular four-stranded non-B DNA structures called G-quadruplexes (G4s) 1 (Fig. 1). G4s arise from...

2017年10月1日 · Recent methodological advances allow us to study G-quadruplex structures at higher resolution and throughput. Approaches to use G-quadruplex structures as molecular tools are highlighted. Computational and experimental methods for G-quadruplex studies are reviewed.

Among these structures are G-quadruplex DNA structures (G4s), which support cellular function by affecting transcription, translation, and telomere maintenance. These structures can also induce genome instability by stalling replication, increasing DNA damage, and …

2021年8月30日 · G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated that G4 DNA structures exist both in cell-free and cellular systems, and function in different diseases, especially in various cancers, aging …

2024年10月18日 · We found that RNA G-quadruplexes (rG4s), which are quadruple-stranded structures formed by contiguous guanines, 26 bind to αSyn and induce aggregation. rG4 itself undergoes LLPS in a Ca 2+ -dependent manner, acting as a scaffold for αSyn aggregation.