Mar 3, 2010 · The concept of gene balance raises several questions with regard to genetic variation and how it affects evolutionary processes that deserve investigation in this context. In this review, we propose integration of the phenotypic data with gene regulatory mechanisms and their impact on quantitative trait control.

The Gene Balance Hypothesis suggests that quantitative traits will be controlled by a large number of genes that can contribute variation. This variation is constrained due to the interacting balance of regulators to a very narrow window around the population norm under most conditions.

Mar 26, 2007 · The concept of genetic balance traces back to the early days of genetics. Additions or subtractions of single chromosomes to the karyotype (aneuploidy) produced greater impacts on the phenotype than whole-genome changes (ploidy).

Jun 20, 2023 · The answer probably differs in each case, but is probably related to the concept of gene balance, which can be summarized as follows: genes, and the proteins they produce, have evolved to function in complex metabolic and regulatory networks. Some of these networks function best when certain enzymes and regulators are present in specific ratios ...

Mar 1, 2007 · The concept of genetic balance traces back to the early days of genetics. Additions or subtractions of single chromosomes to the karyotype (aneuploidy) produced greater impacts on the phenotype...

We summarize, in this review, the evidence that genomic balance influences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number variants and differential evolutionary fate of genes after ...

The gene balance hypothesis: from classical genetics to modern genomics. The gene balance hypothesis: from classical genetics to modern genomics Plant Cell. 2007 Feb;19(2):395-402. doi: 10.1105/tpc.106.049338. Epub 2007 Feb 9. Authors James A Birchler 1 ...

The gene balance hypothesis states that the stoichiometry of members of multisubunit complexes affects the function of the whole because of the kinetics and mode of assembly. Gene regulatory mechanisms also would be governed by these principles. Here, we review the impact of this concept with regard …

The Brassicaceae (Cruciferae) family, owing to its remarkable species, genetic, and physiological diversity as well as its significant economic potential, has become a model for polyploidy and evolutionary studies. Utilizing extensive transcriptome pyrosequencing of diverse taxa, we established a resolved phylogeny of a subset of crucifer species.

Apr 1, 2010 · The gene balance hypothesis is reviewed with regard to the effects on the genetics of quantitative traits, the fate of duplication of genes following polyploidization events or segmental duplication, the basis of aneuploid syndromes, the constraints on cis and trans variation in gene regulation and the potential involvement in hybrid ...