Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin , and by others as a ...

Interferon‐gamma (IFN‐γ) is a cytokine that plays an important role in inducing and modulating an array of immune responses. Cellular responses to IFN‐γ are mediated by its heterodimeric cell‐surface receptor (IFN‐γR), which activates downstream signal transduction cascades, ultimately leading to the regulation of gene expression.

2024年4月19日 · Here we assess the current understanding of IFN-γ, revisit its designation as an "interferon," and weigh its prospects as a therapeutic against globally pervasive microbial pathogens.

Interferons (IFN s, / ˌɪntərˈfɪərɒn / IN-tər-FEER-on[1]) are a group of signaling proteins [2] made and released by host cells in response to the presence of several viruses. In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral defenses.

2024年5月9日 · TB blood tests (interferon-gamma release assay or IGRA) are methods of determining whether a person is infected with TB bacteria. TB blood tests measure the immune response to TB proteins in whole blood.

Originally identified in studies of cellular resistance to viral infection, interferon (IFN)-γ is now known to represent a distinct member of the IFN family and plays critical roles not only in orchestrating both innate and adaptive immune responses ...

2023年7月10日 · Interferons are currently used clinically to treat viral infections such as hepatitis C, cancers including non-Hodgkin’s lymphoma, and autoimmune diseases such as multiple sclerosis. This activity outlines the different types of interferons, namely interferon alpha, beta, …

Interferon gamma is the only type II interferon, classified as such because of its unique amino acid sequence (NCBI amino acid sequence). This interferon is known for its ability to regulate overall immune system functioning (Mitcham, 2005).

Interferon-gamma is a cytokine that plays regulatory roles in both the innate and adaptive immune systems. It is encoded by the IFNG gene and has been associated with protective effects against certain health conditions, such as BPD in infants.

In response to infection, a small protein called interferon-γ (IFN-γ) is synthesized and released by several types of cells belonging to the immune system. IFN-γ acts on both immune and nonimmune cells to provide protection against bacteria, parasites, and fungi.