Because methylene blue can increase serotonin, you would not want to use it alongside these anti-depressant medications as the combination could lead to a dangerous condition known as serotonin syndrome. Here are some scenarios where you would not want to use methylene blue:

In previous blogs, we’ve covered many methylene blue topics including its history, many potential uses (especially as a Health Optimization Nootropic), and we have implored you to never drink actual fish tank cleaner (please!).

Methylene blue is a diagnostic dye and FDA-approved treatment for methemoglobinemia. Learn what else methylene blue is used for, plus the risks, at GoodRx.

Methylene Blue is water-soluble, so you don’t have to take it with food to absorb it well. Taking the supplement with food is better if it causes stomach upset when you take it on an empty stomach. If you take this nootropic on an empty stomach, the short-term effects will kick in faster and be more pronounced.

Yes, methylene blue can be safe for daily use at low doses and under medical supervision. However, discussing supplementation with your healthcare provider is vital, as methylene blue may interact with certain medications.