[25] [26] The polyadenylation signal – the sequence motif recognised by the RNA cleavage complex – varies between groups of eukaryotes. Most human polyadenylation sites contain …

The central sequence motif AAUAAA was identified in the mid-1970s and subsequently shown to require flanking, auxiliary elements for both 3′-end cleavage and polyadenylation of …

2016年3月31日 · What are termination and polyadenylation? The role of the terminator, a sequence-based element, is to define the end of a transcriptional unit (such as a gene) and …

3′‐End processing of eukaryotic mRNAs involves recognition of a polyA signal sequence (PAS) in the nascent pre‐mRNA, followed by endonucleolytic cleavage and polyadenylation of the …

The core pA signal is a bipartite sequence element that constitutes an A-rich hexameric sequence, found 21 nucleotides upstream of the cleavage site 3 and a U and/or G/U rich …

The sequence elements for polyadenylation include the polyadenylation signal (POLYA_SIGNAL) and the polyadenylation site (POLYA_SITE). In mRNA or cDNA the added stretch of …

2024年10月25日 · Polyadenylation signals are integral to mRNA maturation, consisting of specific nucleotide sequences that guide the addition of a poly(A) tail at the 3′ end of the pre-mRNA. …

The central sequence motif AAUAAA was identified in the mid-1970s and subsequently shown to require flanking, auxiliary elements for both 3′-end cleavage and polyadenylation of …

2020年1月6日 · The polyadenylation signal (PAS) sequence is important for the binding and function of the multi-protein polyadenylation complex. The PAS sequence is around 10–30 nt …

Nearly every known mRNA contains a polyadenylation signal sequence, the hexanucleotide AAUAAA, 10–30 bases upstream of the cleavage/polyadenylation site. AAUAAA is found in …