A single-domain antibody (sdAb), also known as a Nanobody, is an antibody fragment consisting of a single monomeric variable antibody domain. Like a whole antibody, it is able to bind …

Here, we review the structural and biophysical properties of VHH domains, highlight recent VHH-based therapeutics and diagnostics, and provide insight into VHH engineering that may pave …

Single-domain antibodies offer unique advantages, including small size, high stability, specificity, ease of production, and low immunogenicity, positioning them as a promising tool for future …

Among the various antibody modalities, single-domain antibodies (sdAbs) may hold the ‘key’ to unlocking the access of antibody therapies to CNS diseases. The unique structural features of …

2024年8月21日 · Heavy-chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains-only that recognize their cognate antigen by virtue …

Over the decades, single-domain antibodies, more frequently referred to as nanobodies, have emerged as a credible next-generation antibody-derived biologics for pharmaceutical and …

Single-domain antibodies or nanobodies are a class of next-generation antibodies that have specific features: small size (in nanoscale), high penetration in various tissues, high stability in …

A single-domain antibody (sdAb) is a type of antibody that consists of only one variable domain of the heavy chain and does not have a light chain. Despite its small size, sdAb has the ability to …

We have established the first dedicated single domain antibody repository and database. The database hosts a large collection of natural and synthetic camelid single domain antibody …

Single-domain antibodies (sdAbs) are exceptionally stable fragments derived from the antigen-binding domains of immunoglobulins.